- Title
- Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus
- Creator
- Elahi, S; Pang, Gerald; Ashman, R; Clancy, Robert
- Relation
- Clinical and Experimental Immunology Vol. 141, no. 1, p. 29-36
- Publisher
- Blackwell Science
- Resource Type
- journal article
- Date
- 2005
- Description
- Orally administered live Lactobacillus acidophilus was assessed for its capacity to enhance clearance from the oral cavity of DBA/2 mice shown previously to be 'infection prone'. L. acidophilus fed to DBA/2 mice significantly shortened the duration of colonization of the oral cavity compared to controls. Enhanced clearance of Candida albicans correlated with both early mRNA gene expression for interleukin (IL)-4 and interferon (IFN)-gamma and expression of their secreted products in cultures of cervical lymph nodes stimulated with Candida antigen. In addition rapid clearance correlated with higher levels of IFN-gamma and nitric oxide in saliva. Delayed clearance, less pronounced levels of the cytokine response, saliva IFN-gamma and nitric oxide, and later mRNA expression for IL-4 and IFN-gamma relative to feeding with the L. acidophilus isolate were noted in mice fed a different Lactobacillus isolate (L. fermentum). These observations indicate significant variations in individual isolates to activate the common mucosal system.
- Subject
- C; albicans; cytokine; lactobacilli; nitric oxide; lactic-acid bacteria; immunodeficient mice; probiotic bacteria; immune-response; streptococcus-thermophilus; immunostimulatory dna; host defense; murine model; mouse
- Identifier
- uon:132
- Identifier
- http://hdl.handle.net/1959.13/25167
- Identifier
- ISSN:1365-2249
- Language
- eng
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